InnateDB Protein
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IDBP-53596.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD74
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Protein Name
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CD74 molecule, major histocompatibility complex, class II invariant chain
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Synonyms
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DHLAG; HLADG; Ia-GAMMA; II;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000367026
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InnateDB Gene
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IDBG-53594 (CD74)
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Protein Structure
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Function |
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
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Subcellular Localization |
Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
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Disease Associations |
Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. {ECO:0000269PubMed:12661006}.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0001516
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prostaglandin biosynthetic process
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GO:0001961
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positive regulation of cytokine-mediated signaling pathway
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GO:0002792
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negative regulation of peptide secretion
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GO:0006461
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protein complex assembly
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GO:0006886
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intracellular protein transport
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GO:0006955
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immune response
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GO:0007165
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signal transduction
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GO:0008283
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cell proliferation
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GO:0016064
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immunoglobulin mediated immune response
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GO:0019882
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antigen processing and presentation
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GO:0019883
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antigen processing and presentation of endogenous antigen
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GO:0019886
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antigen processing and presentation of exogenous peptide antigen via MHC class II
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GO:0030890
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positive regulation of B cell proliferation
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GO:0043030
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regulation of macrophage activation
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GO:0043066
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negative regulation of apoptotic process
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GO:0043518
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negative regulation of DNA damage response, signal transduction by p53 class mediator
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GO:0045058
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T cell selection
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GO:0048146
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positive regulation of fibroblast proliferation
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GO:0050731
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positive regulation of peptidyl-tyrosine phosphorylation
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GO:0060907
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positive regulation of macrophage cytokine production
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GO:0070374
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positive regulation of ERK1 and ERK2 cascade
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GO:0090023
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positive regulation of neutrophil chemotaxis
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GO:1902166
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negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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GO:2000343
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positive regulation of chemokine (C-X-C motif) ligand 2 production
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Cellular Component |
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PDB ID |
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InterPro |
IPR015386
MHC class II-associated invariant chain/CLIP, MHC II-interacting
IPR022339
MHC class II-associated invariant chain
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PFAM |
PF09307
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PRINTS |
PR01990
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PIRSF |
PIRSF001992
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P04233
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PhosphoSite |
PhosphoSite-P04233
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TrEMBL |
O19685
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UniProt Splice Variant |
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Entrez Gene |
972
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UniGene |
Hs.436568
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RefSeq |
NP_001020329
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HUGO |
HGNC:1697
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OMIM |
142790
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CCDS |
CCDS34276
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HPRD |
00825
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IMGT |
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EMBL |
AC011372
AC011388
AK292076
AK297889
BC018726
BC024272
BT019505
CH471062
K01144
M13555
M13556
M13558
M13559
M13560
M28588
X00497
X03339
X03340
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GenPept |
AAA36033
AAA36304
AAA58655
AAH18726
AAH24272
AAV38312
BAF84765
BAG60210
CAA25192
CAA25193
CAA27046
CAA27047
EAW61727
EAW61728
EAW61729
EAW61730
EAW61731
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