InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD74

Summary

InnateDB Protein

IDBP-53598.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD74

Protein Name

CD74 molecule, major histocompatibility complex, class II invariant chain

Synonyms

DHLAG; HLADG; Ia-GAMMA; II;

Species

Homo sapiens

Ensembl Protein

ENSP00000230685

InnateDB Gene

IDBG-53594 (CD74)

Protein Structure

UniProt Annotation

Function

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.

Disease Associations

Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. {ECO:0000269PubMed:12661006}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	13 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004896	cytokine receptor activity
GO:0005515	protein binding
GO:0019955	cytokine binding
GO:0023026	MHC class II protein complex binding
GO:0035718	macrophage migration inhibitory factor binding
GO:0042289	MHC class II protein binding
GO:0042658	MHC class II protein binding, via antigen binding groove
GO:0042802	identical protein binding
GO:0044183	protein binding involved in protein folding

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0001961	positive regulation of cytokine-mediated signaling pathway
GO:0002792	negative regulation of peptide secretion
GO:0006461	protein complex assembly
GO:0006886	intracellular protein transport
GO:0006955	immune response
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0016064	immunoglobulin mediated immune response
GO:0019882	antigen processing and presentation
GO:0019883	antigen processing and presentation of endogenous antigen
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030890	positive regulation of B cell proliferation
GO:0043030	regulation of macrophage activation
GO:0043066	negative regulation of apoptotic process
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045058	T cell selection
GO:0048146	positive regulation of fibroblast proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0060907	positive regulation of macrophage cytokine production
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090023	positive regulation of neutrophil chemotaxis
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005765	lysosomal membrane
GO:0005773	vacuole
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030658	transport vesicle membrane
GO:0030666	endocytic vesicle membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0032588	trans-Golgi network membrane
GO:0035692	macrophage migration inhibitory factor receptor complex
GO:0042613	MHC class II protein complex
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR011988 MHC class II-associated invariant chain, trimerisation
IPR015386 MHC class II-associated invariant chain/CLIP, MHC II-interacting
IPR022339 MHC class II-associated invariant chain

PFAM

PF08831
PF09307

PRINTS

PR01990

PIRSF

PIRSF001992

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt