InnateDB Protein
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IDBP-536092.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Irf1
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Protein Name
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interferon regulatory factor 1
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Synonyms
|
AU020929; Irf-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000118314
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InnateDB Gene
|
IDBG-172251 (Irf1)
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Protein Structure
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|
Function |
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 120 interaction(s) predicted by orthology.
Experimentally validated |
Total |
83
[view]
|
Protein-Protein |
22
[view]
|
Protein-DNA |
61
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
120 [view]
|
|
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Molecular Function |
Accession |
GO Term |
GO:0000975
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regulatory region DNA binding
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GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0043565
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sequence-specific DNA binding
|
|
Biological Process |
GO:0006915
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apoptotic process
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GO:0007050
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cell cycle arrest
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GO:0010468
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regulation of gene expression
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GO:0032728
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positive regulation of interferon-beta production
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GO:0035458
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cellular response to interferon-beta
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GO:0043374
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CD8-positive, alpha-beta T cell differentiation
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GO:0045084
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positive regulation of interleukin-12 biosynthetic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0051607
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defense response to virus
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GO:0071260
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cellular response to mechanical stimulus
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Cellular Component |
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PDB ID |
MGI:96590
|
InterPro |
IPR001346
Interferon regulatory factor DNA-binding domain
|
PFAM |
PF00605
|
PRINTS |
PR00267
|
PIRSF |
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SMART |
SM00348
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TIGRFAMs |
|
Modification |
|
SwissProt |
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
Q5SX16
|
UniProt Splice Variant |
|
Entrez Gene |
16362
|
UniGene |
Mm.399626
|
RefSeq |
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MGI ID |
|
MGI Symbol |
Irf1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AL596182
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GenPept |
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