Version 5.4
Mus musculus Protein: Dhodh
Summary
InnateDB Protein IDBP-536154.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dhodh
Protein Name dihydroorotate dehydrogenase
Synonyms 2810417D19Rik; AI834883;
Species Mus musculus
Ensembl Protein ENSMUSP00000118612
InnateDB Gene IDBG-191275 (Dhodh)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004152 dihydroorotate dehydrogenase activity
GO:0004158 dihydroorotate oxidase activity
GO:0008144 drug binding
GO:0010181 FMN binding
GO:0048039 ubiquinone binding
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0031000 response to caffeine
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0043065 positive regulation of apoptotic process
GO:0055114 oxidation-reduction process
GO:0090140 regulation of mitochondrial fission
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID MGI:1928378
InterPro IPR012135 Dihydroorotate dehydrogenase, class 1/ 2
PFAM PF01180
PRINTS
PIRSF PIRSF000164
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YZY5
UniProt Splice Variant
Entrez Gene 56749
UniGene Mm.411062
RefSeq
MGI ID
MGI Symbol Dhodh
OMIM
CCDS
HPRD
IMGT
EMBL AC125162
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca