InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wisp1

Summary

InnateDB Protein

IDBP-536187.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wisp1

Protein Name

WNT1 inducible signaling pathway protein 1

Synonyms

AW146261; CCN4; Elm1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117402

InnateDB Gene

IDBG-146803 (Wisp1)

Protein Structure

UniProt Annotation

Function

Downstream regulator in the Wnt/Frizzled-signaling pathway (By similarity). Associated with cell survival. Adheres to skin and melanoma fibroblasts (By similarity). In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan (By similarity). Suppresses tumor growth in vivo. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in kidney and lung. Lower levels in heart, brain, spleen, liver, skeletal muscle and testis. Expressed in low metastatic melanoma cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005520	insulin-like growth factor binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007155	cell adhesion
GO:0016055	Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1197008

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O54775

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

22402

UniGene

Mm.10222

RefSeq

MGI ID

MGI Symbol

Wisp1

OMIM

CCDS

HPRD

IMGT

EMBL

AB004873 AF100777 BC048791 BC052677

GenPept

AAC96319 AAH48791 AAH52677 BAA24949