InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casp2

Summary

InnateDB Protein

IDBP-536482.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp2

Protein Name

caspase 2

Synonyms

Caspase-2; ICH-1; Nedd2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121184

InnateDB Gene

IDBG-141522 (Casp2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0035234	ectopic germ cell programmed cell death
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0097190	apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:97295

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001315 CARD domain
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
IPR017350 Caspase, interleukin-1 beta convertase-type

PFAM

PF00619
PF00656

PRINTS

PR00376

PIRSF

PIRSF038001

SMART

SM00114
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References