InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pak3

Summary

InnateDB Protein

IDBP-536533.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pak3

Protein Name

p21 protein (Cdc42/Rac)-activated kinase 3

Synonyms

PAK-3; Pak65alpha; Pak65beta; Stk4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119090

InnateDB Gene

IDBG-176809 (Pak3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0051020	GTPase binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030036	actin cytoskeleton organization
GO:0030833	regulation of actin filament polymerization
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1339656

InterPro

IPR000095 CRIB domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR011009 Protein kinase-like domain

PFAM

PF00786
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00285

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A3KGC5

UniProt Splice Variant

Entrez Gene

18481

UniGene

Mm.474844

RefSeq

MGI ID

MGI Symbol

Pak3

OMIM

CCDS

HPRD

IMGT

EMBL

AL691499 BX322533 BX530055 BX813331

GenPept