InnateDB Protein
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IDBP-536568.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Snapin
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Protein Name
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SNAP-associated protein
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Synonyms
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25kDa; AA407989; AV026596; Bloc1s7; Snap25bp; Snapap;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000122090
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InnateDB Gene
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IDBG-167545 (Snapin)
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Protein Structure
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Function |
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma- membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. {ECO:0000269PubMed:16760431, ECO:0000269PubMed:19546860, ECO:0000269PubMed:21998198}.
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Subcellular Localization |
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Golgi apparatus membrane. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells (By similarity). According to PubMed:12877659 it may be cytoplasmic and peripheral membrane bound. According to PubMed:11283605 it is anchored to the vesicular membrane through an N-terminal signal anchor. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Strongly expressed in heart, brain, testis, kidney and liver; low expression in spleen, lung and skeletal muscle. In the testis, expressed in the seminiferous tubules. {ECO:0000269PubMed:12877659, ECO:0000269PubMed:19168546}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
65 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1333745
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InterPro |
IPR017246
Snapin
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PFAM |
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PRINTS |
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PIRSF |
PIRSF037631
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z266
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PhosphoSite |
PhosphoSite-Q9Z266
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
20615
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UniGene |
Mm.331182
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RefSeq |
NP_598615
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MGI ID |
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MGI Symbol |
Snapin
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OMIM |
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CCDS |
CCDS17531
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HPRD |
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IMGT |
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EMBL |
AF086838
AK007458
AK048007
AK050151
AK077840
AK080718
AK152057
BC006744
BC048691
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GenPept |
AAD11418
AAH06744
AAH48691
BAB25049
BAC33212
BAC34095
BAC37029
BAC37991
BAE30913
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