InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snapin

Summary

InnateDB Protein

IDBP-536568.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snapin

Protein Name

SNAP-associated protein

Synonyms

25kDa; AA407989; AV026596; Bloc1s7; Snap25bp; Snapap;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122090

InnateDB Gene

IDBG-167545 (Snapin)

Protein Structure

UniProt Annotation

Function

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma- membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. {ECO:0000269PubMed:16760431, ECO:0000269PubMed:19546860, ECO:0000269PubMed:21998198}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Golgi apparatus membrane. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells (By similarity). According to PubMed:12877659 it may be cytoplasmic and peripheral membrane bound. According to PubMed:11283605 it is anchored to the vesicular membrane through an N-terminal signal anchor. {ECO:0000250}.

Disease Associations

Tissue Specificity

Strongly expressed in heart, brain, testis, kidney and liver; low expression in spleen, lung and skeletal muscle. In the testis, expressed in the seminiferous tubules. {ECO:0000269PubMed:12877659, ECO:0000269PubMed:19168546}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007268	synaptic transmission
GO:0008089	anterograde axon cargo transport
GO:0010977	negative regulation of neuron projection development
GO:0016079	synaptic vesicle exocytosis
GO:0016188	synaptic vesicle maturation
GO:0017156	calcium ion-dependent exocytosis
GO:0031175	neuron projection development
GO:0031629	synaptic vesicle fusion to presynaptic membrane
GO:0043393	regulation of protein binding
GO:0048489	synaptic vesicle transport
GO:0048490	anterograde synaptic vesicle transport
GO:0072553	terminal button organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005730	nucleolus
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030133	transport vesicle
GO:0030141	secretory granule
GO:0030672	synaptic vesicle membrane
GO:0031083	BLOC-1 complex
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm