Version 5.4
Mus musculus Protein: Dot1l
Summary
InnateDB Protein IDBP-536968.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dot1l
Protein Name DOT1-like, histone H3 methyltransferase (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000116581
InnateDB Gene IDBG-175749 (Dot1l)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity
Biological Process
GO:0016571 histone methylation
GO:0034968 histone lysine methylation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2143886
InterPro IPR013110 Histone methylation DOT1
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF08123
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5YL88
UniProt Splice Variant
Entrez Gene 208266
UniGene Mm.393160
RefSeq
MGI ID
MGI Symbol Dot1l
OMIM
CCDS
HPRD
IMGT
EMBL AC166937 AY377920
GenPept AAQ82850

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca