Version 5.4
Mus musculus Protein: Slu7
Summary
InnateDB Protein IDBP-537195.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slu7
Protein Name SLU7 splicing factor homolog (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000116609
InnateDB Gene IDBG-164064 (Slu7)
Protein Structure
UniProt Annotation
Function Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000386 second spliceosomal transesterification activity
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0030628 pre-mRNA 3'-splice site binding
Biological Process
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0000389 mRNA 3'-splice site recognition
GO:0006886 intracellular protein transport
GO:0034605 cellular response to heat
Cellular Component
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0030532 small nuclear ribonucleoprotein complex
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID MGI:2385598
InterPro IPR001878 Zinc finger, CCHC-type
IPR021715 Pre-mRNA splicing Prp18-interacting factor
PFAM PF00098
PF11708
PRINTS
PIRSF
SMART SM00343
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q8BHJ9
TrEMBL Z4YM25
UniProt Splice Variant
Entrez Gene 193116
UniGene Mm.28200
RefSeq
MGI ID
MGI Symbol Slu7
OMIM
CCDS
HPRD
IMGT
EMBL AL670472
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca