InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gtf2h4

Summary

InnateDB Protein

IDBP-537421.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gtf2h4

Protein Name

general transcription factor II H, polypeptide 4

Synonyms

AW545633; BTF2 p52; p44; p52; TFIIH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124335

InnateDB Gene

IDBG-178785 (Gtf2h4)

Protein Structure

UniProt Annotation

Function

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004003	ATP-dependent DNA helicase activity
GO:0004672	protein kinase activity
GO:0008094	DNA-dependent ATPase activity
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006289	nucleotide-excision repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0032508	DNA duplex unwinding