InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDST1

Summary

InnateDB Protein

IDBP-53743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDST1

Protein Name

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1

Synonyms

HSST; NST1;

Species

Homo sapiens

Ensembl Protein

ENSP00000261797

InnateDB Gene

IDBG-53741 (NDST1)

Protein Structure

UniProt Annotation

Function

Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response. {ECO:0000269PubMed:10758005, ECO:0000269PubMed:12634318}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:9230113}; Single-pass type II membrane protein {ECO:0000269PubMed:9230113}.

Disease Associations

Tissue Specificity

Widely expressed. Expression is most abundant in heart, liver and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity
GO:0016787	hydrolase activity
GO:0019213	deacetylase activity

Biological Process

GO:0000165	MAPK cascade
GO:0000271	polysaccharide biosynthetic process
GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006954	inflammatory response
GO:0007224	smoothened signaling pathway
GO:0007585	respiratory gaseous exchange
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009887	organ morphogenesis
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030210	heparin biosynthetic process
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0044281	small molecule metabolic process
GO:0048702	embryonic neurocranium morphogenesis
GO:0048703	embryonic viscerocranium morphogenesis