Homo sapiens Gene: NDST1
Summary
InnateDB Gene IDBG-53741.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDST1
Gene Name N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Synonyms HSST; NST1;
Species Homo sapiens
Ensembl Gene ENSG00000070614
Encoded Proteins
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:150485818-150558211
Strand Forward strand
Band q33.1
Transcripts
ENST00000261797 ENSP00000261797
ENST00000522491 ENSP00000429966
ENST00000519157 ENSP00000427813
ENST00000524161
ENST00000523767 ENSP00000428604
ENST00000518299 ENSP00000430258
ENST00000518346
ENST00000521752
ENST00000624156
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity
GO:0016787 hydrolase activity
GO:0019213 deacetylase activity
Biological Process
GO:0000165 MAPK cascade
GO:0000271 polysaccharide biosynthetic process
GO:0005975 carbohydrate metabolic process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006954 inflammatory response
GO:0007224 smoothened signaling pathway
GO:0007585 respiratory gaseous exchange
GO:0008152 metabolic process
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009887 organ morphogenesis
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030203 glycosaminoglycan metabolic process
GO:0030210 heparin biosynthetic process
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0044281 small molecule metabolic process
GO:0048702 embryonic neurocranium morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mucopolysaccharidoses pathway
Myoclonic epilepsy of Lafora pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
Defective SLC26A2 causes chondrodysplasias pathway
HS-GAG biosynthesis pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Heparan sulfate/heparin (HS-GAG) metabolism pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
Glycosaminoglycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.222055
RefSeq NM_001301063 NM_001543 XM_005268439 XM_005268440 XM_006714783
HUGO
OMIM
CCDS CCDS34277 CCDS75358
HPRD 02912
IMGT
EMBL
GenPept
RNA Seq Atlas