InnateDB Protein
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IDBP-537449.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sorbs2
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Protein Name
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sorbin and SH3 domain containing 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000123503
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InnateDB Gene
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IDBG-152757 (Sorbs2)
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Protein Structure
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Function |
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Found at the Z line sarcomeres, stress fibers, dense bodies and focal adhesion. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
28 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1924574
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InterPro |
IPR003127
Sorbin-like
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PFAM |
PF02208
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PRINTS |
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PIRSF |
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SMART |
SM00459
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TIGRFAMs |
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Modification |
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SwissProt |
Q3UTJ2
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PhosphoSite |
PhosphoSite-Q3UTJ2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
234214
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UniGene |
Mm.489875
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RefSeq |
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MGI ID |
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MGI Symbol |
Sorbs2
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK041051
AK049030
AK079130
AK083429
AK122369
AK139388
AK140498
BC039163
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GenPept |
AAH39163
BAC30799
BAC33518
BAC37554
BAC38913
BAC65651
BAE23988
BAE24407
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