InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptprr

Summary

InnateDB Protein

IDBP-537543.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprr

Protein Name

protein tyrosine phosphatase, receptor type, R

Synonyms

Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114455

InnateDB Gene

IDBG-191106 (Ptprr)

Protein Structure

UniProt Annotation

Function

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton. {ECO:0000269PubMed:10601328, ECO:0000269PubMed:10949045}.

Subcellular Localization

Isoform Alpha: Cell membrane; Single-pass type I membrane protein.Isoform Beta: Cytoplasm. Note=Locates to the areas within the cytoplasm.Isoform Gamma: Cytoplasm. Note=Locates to the areas within the cytoplasm.

Disease Associations

Tissue Specificity

Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Isoform alpha is expressed throughout the granular layer of the cerebellar but not within the Purkinje cells, also in the villi of the ileum and jejunum and both the villi and crypts of the duodenum. Isoform beta is expressed only in the Purkinje cells. Isoform gamma is expressed throughout the brain, the villi and crypts of the duodenum, jejunum and ileum and expressed at low levels in the proximal colon. {ECO:0000269PubMed:10705342, ECO:0000269PubMed:10949045, ECO:0000269PubMed:7832766, ECO:0000269PubMed:7836467}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:109559

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR008356 Protein-tyrosine phosphatase, KIM-containing
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102

PRINTS

PR00700
PR01778

PIRSF

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt