InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HMOX1

Summary

InnateDB Protein

IDBP-5376.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMOX1

Protein Name

heme oxygenase (decycling) 1

Synonyms

bK286B10; HMOX1D; HO-1; HSP32;

Species

Homo sapiens

Ensembl Protein

ENSP00000216117

InnateDB Gene

IDBG-5374 (HMOX1)

Protein Structure

UniProt Annotation

Function

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.

Subcellular Localization

Microsome {ECO:0000269PubMed:22419571}. Endoplasmic reticulum membrane {ECO:0000269PubMed:22419571}; Peripheral membrane protein {ECO:0000269PubMed:22419571}; Cytoplasmic side {ECO:0000269PubMed:22419571}.

Disease Associations

Heme oxygenase 1 deficiency (HMOX1D) [MIM:614034]: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. {ECO:0000269PubMed:9884342}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level). {ECO:0000269PubMed:20855888}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	5 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004392	heme oxygenase (decyclizing) activity
GO:0004630	phospholipase D activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0001935	endothelial cell proliferation
GO:0002246	wound healing involved in inflammatory response
GO:0002686	negative regulation of leukocyte migration
GO:0006778	porphyrin-containing compound metabolic process
GO:0006788	heme oxidation
GO:0006879	cellular iron ion homeostasis
GO:0006979	response to oxidative stress
GO:0007264	small GTPase mediated signal transduction
GO:0007588	excretion
GO:0008217	regulation of blood pressure
GO:0008219	cell death
GO:0008285	negative regulation of cell proliferation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010656	negative regulation of muscle cell apoptotic process
GO:0014806	smooth muscle hyperplasia
GO:0031670	cellular response to nutrient
GO:0032764	negative regulation of mast cell cytokine production
GO:0034101	erythrocyte homeostasis
GO:0034383	low-density lipoprotein particle clearance
GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron
GO:0035094	response to nicotine
GO:0035556	intracellular signal transduction
GO:0042167	heme catabolic process
GO:0042168	heme metabolic process
GO:0042542	response to hydrogen peroxide
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043305	negative regulation of mast cell degranulation
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043627	response to estrogen
GO:0044281	small molecule metabolic process
GO:0045080	positive regulation of chemokine biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045765	regulation of angiogenesis
GO:0045766	positive regulation of angiogenesis
GO:0045909	positive regulation of vasodilation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0051260	protein homooligomerization
GO:0055072	iron ion homeostasis
GO:0055085	transmembrane transport
GO:0055114	oxidation-reduction process
GO:0071243	cellular response to arsenic-containing substance
GO:0071276	cellular response to cadmium ion
GO:0071456	cellular response to hypoxia
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005901	caveola
GO:0016020	membrane