Homo sapiens Protein: HMOX1
InnateDB Protein IDBP-5376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMOX1
Protein Name heme oxygenase (decycling) 1
Synonyms bK286B10; HMOX1D; HO-1; HSP32;
Species Homo sapiens
Ensembl Protein ENSP00000216117
InnateDB Gene IDBG-5374 (HMOX1)
Protein Structure
UniProt Annotation
Function Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Subcellular Localization Microsome {ECO:0000269PubMed:22419571}. Endoplasmic reticulum membrane {ECO:0000269PubMed:22419571}; Peripheral membrane protein {ECO:0000269PubMed:22419571}; Cytoplasmic side {ECO:0000269PubMed:22419571}.
Disease Associations Heme oxygenase 1 deficiency (HMOX1D) [MIM:614034]: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. {ECO:0000269PubMed:9884342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level). {ECO:0000269PubMed:20855888}.
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 5 [view]
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004392 heme oxygenase (decyclizing) activity
GO:0004630 phospholipase D activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001935 endothelial cell proliferation
GO:0002246 wound healing involved in inflammatory response
GO:0002686 negative regulation of leukocyte migration
GO:0006778 porphyrin-containing compound metabolic process
GO:0006788 heme oxidation
GO:0006879 cellular iron ion homeostasis
GO:0006979 response to oxidative stress
GO:0007264 small GTPase mediated signal transduction
GO:0007588 excretion
GO:0008217 regulation of blood pressure
GO:0008219 cell death
GO:0008285 negative regulation of cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0014806 smooth muscle hyperplasia
GO:0031670 cellular response to nutrient
GO:0032764 negative regulation of mast cell cytokine production
GO:0034101 erythrocyte homeostasis
GO:0034383 low-density lipoprotein particle clearance
GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron
GO:0035094 response to nicotine
GO:0035556 intracellular signal transduction
GO:0042167 heme catabolic process
GO:0042168 heme metabolic process
GO:0042542 response to hydrogen peroxide
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043305 negative regulation of mast cell degranulation
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043627 response to estrogen
GO:0044281 small molecule metabolic process
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045909 positive regulation of vasodilation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051260 protein homooligomerization
GO:0055072 iron ion homeostasis
GO:0055085 transmembrane transport
GO:0055114 oxidation-reduction process
GO:0071243 cellular response to arsenic-containing substance
GO:0071276 cellular response to cadmium ion
GO:0071456 cellular response to hypoxia
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005901 caveola
GO:0016020 membrane
Protein Structure and Domains
InterPro IPR002051 Haem oxygenase
IPR016053 Haem oxygenase-like
IPR016084 Haem oxygenase-like, multi-helical
PFAM PF01126
Post-translational Modifications
SwissProt P09601
PhosphoSite PhosphoSite-P09601
UniProt Splice Variant
Entrez Gene 3162
RefSeq NP_002124
OMIM 141250
HPRD 00782
EMBL AY460337 BT019785 CH471095 CR456505 CR541945 CR541968 GU187011 GU187012 M23041 X06985 X14782 Z82244
GenPept AAA50403 AAR23262 AAV38588 ACZ72606 ACZ72607 CAA30045 CAA32886 CAB05109 CAG30391 CAG46743 CAG46766 EAW60059