Version 5.4
Homo sapiens Gene: HMOX1
Summary
InnateDB Gene IDBG-5374.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMOX1
Gene Name heme oxygenase (decycling) 1
Synonyms bK286B10; HMOX1D; HO-1; HSP32
Species Homo sapiens
Ensembl Gene ENSG00000100292
Encoded Proteins
IDBP-5376
heme oxygenase (decycling) 1
IDBP-374188
heme oxygenase (decycling) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21307647
HMOX1, a downstream signalling molecule in the TLR4 pathway, is necessary for LPS-induced autophagy signalling in macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 21307647
[Mus musculus] Hmox1, a downstream signalling molecule in the Tlr4 pathway, is necessary for LPS-induced autophagy signalling in macrophages.
Entrez Gene
Summary Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:35380361-35394214
Strand Forward strand
Band q12.3
Transcripts
ENST00000216117 ENSP00000216117
ENST00000412893 ENSP00000413316
ENST00000481190
ENST00000494998
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 5 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004392 heme oxygenase (decyclizing) activity
GO:0004630 phospholipase D activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001935 endothelial cell proliferation
GO:0002246 wound healing involved in inflammatory response
GO:0002686 negative regulation of leukocyte migration
GO:0006778 porphyrin-containing compound metabolic process
GO:0006788 heme oxidation
GO:0006879 cellular iron ion homeostasis
GO:0006979 response to oxidative stress
GO:0007264 small GTPase mediated signal transduction
GO:0007588 excretion
GO:0008217 regulation of blood pressure
GO:0008219 cell death
GO:0008285 negative regulation of cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0014806 smooth muscle hyperplasia
GO:0031670 cellular response to nutrient
GO:0032764 negative regulation of mast cell cytokine production
GO:0034101 erythrocyte homeostasis
GO:0034383 low-density lipoprotein particle clearance
GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron
GO:0035094 response to nicotine
GO:0035556 intracellular signal transduction
GO:0042167 heme catabolic process
GO:0042168 heme metabolic process
GO:0042542 response to hydrogen peroxide
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043305 negative regulation of mast cell degranulation
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043627 response to estrogen
GO:0044281 small molecule metabolic process
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045909 positive regulation of vasodilation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051260 protein homooligomerization
GO:0055072 iron ion homeostasis
GO:0055085 transmembrane transport
GO:0055114 oxidation-reduction process
GO:0071243 cellular response to arsenic-containing substance
GO:0071276 cellular response to cadmium ion
GO:0071456 cellular response to hypoxia
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005901 caveola
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005413
View Gene Order
ENSBTAG00000015582
Not yet available
Pathways
NETPATH
REACTOME
REACT_25060
Iron uptake and transport pathway
REACT_22297
Heme degradation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt P09601
TrEMBL B1AHA8 D2K7W4 Q6FH11
UniProt Splice Variant
Entrez Gene 3162
UniGene
RefSeq NM_002133
HUGO HGNC:5013
OMIM 141250
CCDS CCDS13914
HPRD 00782
IMGT
EMBL AY460337 BT019785 CH471095 CR456505 CR541945 CR541968 GU187011 GU187012 M23041 X06985 X14782 Z82244
GenPept AAA50403 AAR23262 AAV38588 ACZ72606 ACZ72607 CAA30045 CAA32886 CAB05109 CAG30391 CAG46743 CAG46766 EAW60059
RNA Seq Atlas 3162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca