InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nme1

Summary

InnateDB Protein

IDBP-537769.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nme1

Protein Name

non-metastatic cells 1, protein (NM23A) expressed in

Synonyms

AL024257; NDPK-A; NM23-M1; NM23A;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117022

InnateDB Gene

IDBG-208565 (Nme1)

Protein Structure

UniProt Annotation

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Note=This protein is found in reduced amount in tumor cells of high metastatic potential.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003697	single-stranded DNA binding
GO:0004536	deoxyribonuclease activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0019215	intermediate filament binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0043015	gamma-tubulin binding
GO:0043024	ribosomal small subunit binding

Biological Process

GO:0002762	negative regulation of myeloid leukocyte differentiation
GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006308	DNA catabolic process
GO:0006897	endocytosis
GO:0007595	lactation
GO:0010629	negative regulation of gene expression
GO:0010976	positive regulation of neuron projection development
GO:0014075	response to amine
GO:0021766	hippocampus development
GO:0030879	mammary gland development
GO:0033574	response to testosterone
GO:0035690	cellular response to drug
GO:0043388	positive regulation of DNA binding
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051591	response to cAMP
GO:0071333	cellular response to glucose stimulus
GO:0071398	cellular response to fatty acid