InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nme1

Summary

InnateDB Gene

IDBG-208565.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nme1

Gene Name

NME/NM23 nucleoside diphosphate kinase 1

Synonyms

AL024257; NDPK-A; NM23-M1; NM23A

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037601

Encoded Proteins

IDBP-208567

non-metastatic cells 1, protein (NM23A) expressed in

IDBP-265820

non-metastatic cells 1, protein (NM23A) expressed in

IDBP-537769

non-metastatic cells 1, protein (NM23A) expressed in

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000239672:
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of \'A\' (encoded by this gene) and \'B\' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:93956979-93968521

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021220	ENSMUSP00000021220
ENSMUST00000107844	ENSMUSP00000103475
ENSMUST00000135884	ENSMUSP00000117022

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003697	single-stranded DNA binding
GO:0004536	deoxyribonuclease activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0019215	intermediate filament binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0043015	gamma-tubulin binding
GO:0043024	ribosomal small subunit binding

Biological Process

GO:0002762	negative regulation of myeloid leukocyte differentiation
GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006308	DNA catabolic process
GO:0006897	endocytosis
GO:0007595	lactation
GO:0010629	negative regulation of gene expression
GO:0010976	positive regulation of neuron projection development
GO:0014075	response to amine
GO:0021766	hippocampus development
GO:0030879	mammary gland development
GO:0033574	response to testosterone
GO:0035690	cellular response to drug
GO:0043388	positive regulation of DNA binding
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051591	response to cAMP
GO:0071333	cellular response to glucose stimulus
GO:0071398	cellular response to fatty acid