InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRN

Summary

InnateDB Protein

IDBP-53784.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRN

Protein Name

granulin

Synonyms

CLN11; GEP; GP88; PCDGF; PEPI; PGRN;

Species

Homo sapiens

Ensembl Protein

ENSP00000053867

InnateDB Gene

IDBG-53782 (GRN)

Protein Structure

UniProt Annotation

Function

Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

Subcellular Localization

Secreted.

Disease Associations

Ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]: Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. Note=The disease is caused by mutations affecting the gene represented in this entry.Ceroid lipofuscinosis, neuronal, 11 (CLN11) [MIM:614706]: A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. {ECO:0000269PubMed:22608501}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001835	blastocyst hatching
GO:0007165	signal transduction
GO:0007566	embryo implantation
GO:0008219	cell death
GO:0045087	innate immune response (InnateDB)
GO:0050679	positive regulation of epithelial cell proliferation