InnateDB: Systems Biology of the Innate Immune Response

GRN is an essential secreted cofactor that potentiates TLR9-driven response to CpG olignonucletides by binding directly to CpG oligos and TLR9. GRN deficient murine macrophages showed impaired delivery of CpG oligos to endolysosomal compartments and reduced response to CpG. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21497117

[Mus musculus] Grn is an essential secreted cofactor that potentiates Tlr9-driven response to CpG olignonucletides by binding directly to CpG oligos and Tlr9. Grn deficient murine macrophages showed impaired delivery of CpG oligos to endolysosomal compartments and reduced response to CpG.

Entrez Gene

Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:44345246-44353102

Strand

Forward strand

Band

q21.31

Transcripts

ENST00000053867	ENSP00000053867
ENST00000587387	ENSP00000467431
ENST00000592783	ENSP00000467870
ENST00000586242	ENSP00000467837
ENST00000590984
ENST00000587109	ENSP00000466271
ENST00000593167	ENSP00000466405
ENST00000591740	ENSP00000467022
ENST00000587958
ENST00000586443	ENSP00000465673
ENST00000585348
ENST00000589536	ENSP00000466956
ENST00000585512	ENSP00000467745
ENST00000587518	ENSP00000465518
ENST00000589265	ENSP00000467616
ENST00000588170
ENST00000589923
ENST00000592323
ENST00000588237	ENSP00000466611
ENST00000588143	ENSP00000465375
ENST00000586782	ENSP00000468318

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001835	blastocyst hatching
GO:0007165	signal transduction
GO:0007566	embryo implantation
GO:0008219	cell death
GO:0045087	innate immune response (InnateDB)
GO:0050679	positive regulation of epithelial cell proliferation

Cellular Component

GO:0005615	extracellular space
GO:0005739	mitochondrion
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000034708

View Gene Order

ENSBTAG00000018823

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.514220 Hs.602870 Hs.743935

RefSeq

NM_002087 XM_005257253

HUGO

OMIM

CCDS

CCDS11483

HPRD

00733

IMGT

EMBL

GenPept

RNA Seq Atlas