Homo sapiens Gene: GRN
Summary
InnateDB Gene IDBG-53782.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRN
Gene Name granulin
Synonyms CLN11; GEP; GP88; PCDGF; PEPI; PGRN;
Species Homo sapiens
Ensembl Gene ENSG00000030582
Encoded Proteins
granulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
GRN is an essential secreted cofactor that potentiates TLR9-driven response to CpG olignonucletides by binding directly to CpG oligos and TLR9. GRN deficient murine macrophages showed impaired delivery of CpG oligos to endolysosomal compartments and reduced response to CpG. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Grn is an essential secreted cofactor that potentiates Tlr9-driven response to CpG olignonucletides by binding directly to CpG oligos and Tlr9. Grn deficient murine macrophages showed impaired delivery of CpG oligos to endolysosomal compartments and reduced response to CpG.
Entrez Gene
Summary Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:44345246-44353102
Strand Forward strand
Band q21.31
Transcripts
ENST00000053867 ENSP00000053867
ENST00000587387 ENSP00000467431
ENST00000592783 ENSP00000467870
ENST00000586242 ENSP00000467837
ENST00000590984
ENST00000587109 ENSP00000466271
ENST00000593167 ENSP00000466405
ENST00000591740 ENSP00000467022
ENST00000587958
ENST00000586443 ENSP00000465673
ENST00000585348
ENST00000589536 ENSP00000466956
ENST00000585512 ENSP00000467745
ENST00000587518 ENSP00000465518
ENST00000589265 ENSP00000467616
ENST00000588170
ENST00000589923
ENST00000592323
ENST00000588237 ENSP00000466611
ENST00000588143 ENSP00000465375
ENST00000586782 ENSP00000468318
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001835 blastocyst hatching
GO:0007165 signal transduction
GO:0007566 embryo implantation
GO:0008219 cell death
GO:0045087 innate immune response (InnateDB)
GO:0050679 positive regulation of epithelial cell proliferation
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL K7EK92 K7ELY1 K7EM89 K7ENI2 K7ENN1 K7EQ05 K7EQA7 K7EQK6
UniProt Splice Variant
Entrez Gene 2896
UniGene Hs.514220 Hs.602870 Hs.743935
RefSeq NM_002087 XM_005257253
HUGO HGNC:4601
OMIM 138945
CCDS CCDS11483
HPRD 00733
IMGT
EMBL AC003043
GenPept
RNA Seq Atlas 2896