|Homo sapiens Gene: GRN|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Synonyms||CLN11; GEP; GP88; PCDGF; PEPI; PGRN;|
|Useful resources||Stemformatics EHFPI ImmGen|
GRN is an essential secreted cofactor that potentiates TLR9-driven response to CpG olignonucletides by binding directly to CpG oligos and TLR9. GRN deficient murine macrophages showed impaired delivery of CpG oligos to endolysosomal compartments and reduced response to CpG. (Demonstrated in murine model)
|InnateDB Annotation from Orthologs|
[Mus musculus] Grn is an essential secreted cofactor that potentiates Tlr9-driven response to CpG olignonucletides by binding directly to CpG oligos and Tlr9. Grn deficient murine macrophages showed impaired delivery of CpG oligos to endolysosomal compartments and reduced response to CpG.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 17:44345246-44353102|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|TrEMBL||K7EK92 K7ELY1 K7EM89 K7ENI2 K7ENN1 K7EQ05 K7EQA7 K7EQK6|
|UniProt Splice Variant|
|UniGene||Hs.514220 Hs.602870 Hs.743935|
|RNA Seq Atlas||2896|