InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgs2

Summary

InnateDB Protein

IDBP-537926.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs2

Protein Name

regulator of G-protein signaling 2

Synonyms

GOS8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115558

InnateDB Gene

IDBG-197102 (Rgs2)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.

Subcellular Localization

Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in a wide variety of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0006417	regulation of translation
GO:0007049	cell cycle
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007283	spermatogenesis
GO:0010519	negative regulation of phospholipase activity
GO:0010614	negative regulation of cardiac muscle hypertrophy
GO:0031116	positive regulation of microtubule polymerization
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043407	negative regulation of MAP kinase activity
GO:0043547	positive regulation of GTPase activity
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0045087	innate immune response (InnateDB)
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0050873	brown fat cell differentiation
GO:0055119	relaxation of cardiac muscle
GO:0060087	relaxation of vascular smooth muscle
GO:0060452	positive regulation of cardiac muscle contraction
GO:0071877	regulation of adrenergic receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009898	cytoplasmic side of plasma membrane
GO:0043005	neuron projection