Mus musculus Gene: Rgs2
Summary
InnateDB Gene IDBG-197102.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rgs2
Gene Name regulator of G-protein signaling 2
Synonyms GOS8;
Species Mus musculus
Ensembl Gene ENSMUSG00000026360
Encoded Proteins
regulator of G-protein signaling 2
regulator of G-protein signaling 2
regulator of G-protein signaling 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Rgs2 negatively regulates Nox1 expression and consequently inhibits reactive oxygen species production in TLR-mediate innate immune responses.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] RGS2 negatively regulates NOX1 expression and consequently inhibits reactive oxygen species production in TLR-mediated innate immune responses. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116741:
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:143999338-144004161
Strand Reverse strand
Band F
Transcripts
ENSMUST00000027606 ENSMUSP00000139964
ENSMUST00000127206 ENSMUSP00000115558
ENSMUST00000153527 ENSMUSP00000140548
ENSMUST00000134817
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0006417 regulation of translation
GO:0007049 cell cycle
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007283 spermatogenesis
GO:0010519 negative regulation of phospholipase activity
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0031116 positive regulation of microtubule polymerization
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043407 negative regulation of MAP kinase activity
GO:0043547 positive regulation of GTPase activity
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0045087 innate immune response (InnateDB)
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0050873 brown fat cell differentiation
GO:0055119 relaxation of cardiac muscle
GO:0060087 relaxation of vascular smooth muscle
GO:0060452 positive regulation of cardiac muscle contraction
GO:0071877 regulation of adrenergic receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0043005 neuron projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Signaling by GPCR pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O08849
TrEMBL
UniProt Splice Variant
Entrez Gene 19735
UniGene Mm.28262
RefSeq NM_009061
OMIM
CCDS CCDS15347
HPRD
IMGT
MGI ID MGI:1098271
MGI Symbol Rgs2
EMBL AF215668 AF432916 AK031603 AK077922 AK162276 BC023001 U67187
GenPept AAB50617 AAF34625 AAH23001 AAL28114 BAC27471 BAC37065 BAE36830
RNA Seq Atlas 19735