InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rgs2

Summary

InnateDB Gene

IDBG-197102.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs2

Gene Name

regulator of G-protein signaling 2

Synonyms

GOS8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026360

Encoded Proteins

IDBP-788335

regulator of G-protein signaling 2

IDBP-537926

regulator of G-protein signaling 2

IDBP-788337

regulator of G-protein signaling 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22120521

Rgs2 negatively regulates Nox1 expression and consequently inhibits reactive oxygen species production in TLR-mediate innate immune responses.

InnateDB Annotation from Orthologs

Summary

PMID 22120521

[Homo sapiens] RGS2 negatively regulates NOX1 expression and consequently inhibits reactive oxygen species production in TLR-mediated innate immune responses. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116741:
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:143999338-144004161

Strand

Reverse strand

Band

Transcripts

ENSMUST00000027606	ENSMUSP00000139964
ENSMUST00000127206	ENSMUSP00000115558
ENSMUST00000153527	ENSMUSP00000140548
ENSMUST00000134817

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0006417	regulation of translation
GO:0007049	cell cycle
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007283	spermatogenesis
GO:0010519	negative regulation of phospholipase activity
GO:0010614	negative regulation of cardiac muscle hypertrophy
GO:0031116	positive regulation of microtubule polymerization
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043407	negative regulation of MAP kinase activity
GO:0043547	positive regulation of GTPase activity
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0045087	innate immune response (InnateDB)
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0050873	brown fat cell differentiation
GO:0055119	relaxation of cardiac muscle
GO:0060087	relaxation of vascular smooth muscle
GO:0060452	positive regulation of cardiac muscle contraction
GO:0071877	regulation of adrenergic receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009898	cytoplasmic side of plasma membrane
GO:0043005	neuron projection