InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS54

Summary

InnateDB Protein

IDBP-53801.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS54

Protein Name

vacuolar protein sorting 54 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000272322

InnateDB Gene

IDBG-53799 (VPS54)

Protein Structure

UniProt Annotation

Function

May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. {ECO:0000269PubMed:18367545}.

Subcellular Localization

Golgi apparatus, trans-Golgi network {ECO:0000269PubMed:18367545}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0015031	protein transport
GO:0040007	growth
GO:0042147	retrograde transport, endosome to Golgi
GO:0048873	homeostasis of number of cells within a tissue
GO:0050881	musculoskeletal movement
GO:0060052	neurofilament cytoskeleton organization