InnateDB Protein
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IDBP-53803.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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VPS54
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Protein Name
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vacuolar protein sorting 54 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000346499
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InnateDB Gene
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IDBG-53799 (VPS54)
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Protein Structure
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Function |
May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. {ECO:0000269PubMed:18367545}.
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Subcellular Localization |
Golgi apparatus, trans-Golgi network {ECO:0000269PubMed:18367545}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR012501
Vps54-like
IPR019515
Vacuolar protein sorting-associated protein 54
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PFAM |
PF07928
PF10475
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9P1Q0
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PhosphoSite |
PhosphoSite-Q9P1Q0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51542
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UniGene |
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RefSeq |
XP_006712092
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HUGO |
HGNC:18652
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OMIM |
614633
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CCDS |
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HPRD |
10302
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IMGT |
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EMBL |
AF102177
AK002205
AL137604
AL359939
AY444798
BC030275
BC041868
CR749701
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GenPept |
AAF37319
AAH30275
AAH41868
AAS20945
BAA92134
CAB70837
CAB95772
CAH18479
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