InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grip1

Summary

InnateDB Protein

IDBP-538177.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grip1

Protein Name

glutamate receptor interacting protein 1

Synonyms

4931400F03Rik; eb; GRIP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121670

InnateDB Gene

IDBG-192287 (Grip1)

Protein Structure

UniProt Annotation

Function

May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle. Endoplasmic reticulum. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Note=Cytoplasmic and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities (By similarity). The palmitoylated form of isoform 2 is exclusively membrane- associated. {ECO:0000250}.Isoform 2: Membrane; Lipid-anchor.

Disease Associations

Tissue Specificity

Expressed in brain. Isoform 2 is the major isoform in brain. Expressed in oligodendrocyte lineage cells. {ECO:0000269PubMed:11335060, ECO:0000269PubMed:12458226}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0008104

protein localization

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0045121	membrane raft
GO:0045211	postsynaptic membrane
GO:0055037	recycling endosome