Mus musculus Gene: Grip1
Summary
InnateDB Gene IDBG-192287.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grip1
Gene Name glutamate receptor interacting protein 1
Synonyms 4931400F03Rik; eb; GRIP;
Species Mus musculus
Ensembl Gene ENSMUSG00000034813
Encoded Proteins
glutamate receptor interacting protein 1
glutamate receptor interacting protein 1
glutamate receptor interacting protein 1
glutamate receptor interacting protein 1
glutamate receptor interacting protein 1
glutamate receptor interacting protein 1
glutamate receptor interacting protein 1
glutamate receptor interacting protein 1
glutamate receptor interacting protein 1
glutamate receptor interacting protein 1
glutamate receptor interacting protein 1
glutamate receptor interacting protein 1
glutamate receptor interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein containing multiple PDZ (post synaptic density protein, Drosophila disc large tumor suppressor, and zonula occludens-1 protein) domains. The encoded protein acts as a mediator between cytoskeletal and membrane proteins, particularly in neuronal cells, and facilitates complex formation at the cell membrane. Mutation of this gene can cause embryonic lethality resulting from defects of the dermo-epidermal junction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:119454034-120087261
Strand Forward strand
Band D2
Transcripts
ENSMUST00000041962 ENSMUSP00000042436
ENSMUST00000077871 ENSMUSP00000077033
ENSMUST00000081260 ENSMUSP00000080016
ENSMUST00000105262 ENSMUSP00000100897
ENSMUST00000105261 ENSMUSP00000100896
ENSMUST00000147356 ENSMUSP00000115478
ENSMUST00000147454 ENSMUSP00000118073
ENSMUST00000147598
ENSMUST00000138410 ENSMUSP00000123234
ENSMUST00000144825 ENSMUSP00000121670
ENSMUST00000148954 ENSMUSP00000118397
ENSMUST00000144959 ENSMUSP00000122323
ENSMUST00000139352
ENSMUST00000127787
ENSMUST00000130387 ENSMUSP00000123288
ENSMUST00000154238 ENSMUSP00000122349
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0008104 protein localization
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030054 cell junction
GO:0030425 dendrite
GO:0043005 neuron projection
GO:0045121 membrane raft
GO:0045211 postsynaptic membrane
GO:0055037 recycling endosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Neuronal System pathway
Trafficking of GluR2-containing AMPA receptors pathway
Trafficking of AMPA receptors pathway
Transmission across Chemical Synapses pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Neuronal System pathway
Trafficking of AMPA receptors pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Trafficking of GluR2-containing AMPA receptors pathway
KEGG
INOH
PID BIOCARTA
Role of erbb2 in signal transduction and oncology [Biocarta view]
Control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) [Biocarta view]
Carm1 and regulation of the estrogen receptor [Biocarta view]
PID NCI
Cross-References
SwissProt Q925T6
TrEMBL
UniProt Splice Variant
Entrez Gene 74053
UniGene Mm.196692 Mm.489493
RefSeq NM_028736 XM_006514231 XM_006514232 XM_006514234 XM_006514235 XM_006514238 XM_006514239 XM_006514242 NM_001277292 NM_001277293 NM_001277294 NM_001277295 NM_130891 NM_133442 XM_006514233 XM_006514236 XM_006514237 XM_006514241 XM_006514244
OMIM
CCDS CCDS24202 CCDS36071 CCDS36072 CCDS70111 CCDS70112 CCDS70113 CCDS70114
HPRD
IMGT
MGI ID MGI:1921303
MGI Symbol Grip1
EMBL AB051560 AB051561 AB051562 AK029905 AK043821
GenPept BAB46929 BAB46930 BAB46931 BAC26668 BAC31662
RNA Seq Atlas 74053