Version 5.4
Mus musculus Protein: Il21
Summary
InnateDB Protein IDBP-538228.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il21
Protein Name interleukin 21
Synonyms IL-21;
Species Mus musculus
Ensembl Protein ENSMUSP00000124668
InnateDB Gene IDBG-140267 (Il21)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 0
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
Biological Process
GO:0002729 positive regulation of natural killer cell cytokine production
GO:0006955 immune response
GO:0032733 positive regulation of interleukin-10 production
GO:0032825 positive regulation of natural killer cell differentiation
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:1890474
InterPro IPR003443 Interleukin-15/Interleukin-21 family
PFAM PF02372
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PX58
UniProt Splice Variant
Entrez Gene 60505
UniGene Mm.157689
RefSeq NP_001277970
MGI ID
MGI Symbol Il21
OMIM
CCDS CCDS71236
HPRD
IMGT
EMBL AL662823
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca