Mus musculus Protein: Akt1
InnateDB Protein IDBP-538336.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akt1
Protein Name thymoma viral proto-oncogene 1
Synonyms Akt; PKB; PKB/Akt; PKBalpha; Rac;
Species Mus musculus
Ensembl Protein ENSMUSP00000123689
InnateDB Gene IDBG-174623 (Akt1)
Protein Structure
UniProt Annotation
Subcellular Localization
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 254 interaction(s) predicted by orthology.
Experimentally validated
Total 86 [view]
Protein-Protein 86 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 254 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030235 nitric-oxide synthase regulator activity
GO:0042802 identical protein binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0001649 osteoblast differentiation
GO:0001893 maternal placenta development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006412 translation
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006924 activation-induced cell death of T cells
GO:0006954 inflammatory response
GO:0007281 germ cell development
GO:0007568 aging
GO:0008637 apoptotic mitochondrial changes
GO:0010507 negative regulation of autophagy
GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport
GO:0010765 positive regulation of sodium ion transport
GO:0010951 negative regulation of endopeptidase activity
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0030030 cell projection organization
GO:0030163 protein catabolic process
GO:0030212 hyaluronan metabolic process
GO:0030307 positive regulation of cell growth
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0031999 negative regulation of fatty acid beta-oxidation
GO:0032094 response to food
GO:0032287 peripheral nervous system myelin maintenance
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032869 cellular response to insulin stimulus
GO:0032880 regulation of protein localization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034405 response to fluid shear stress
GO:0035556 intracellular signal transduction
GO:0042593 glucose homeostasis
GO:0042640 anagen
GO:0043065 positive regulation of apoptotic process
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045600 positive regulation of fat cell differentiation
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045792 negative regulation of cell size
GO:0045861 negative regulation of proteolysis
GO:0045907 positive regulation of vasoconstriction
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046326 positive regulation of glucose import
GO:0046329 negative regulation of JNK cascade
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0060709 glycogen cell differentiation involved in embryonic placenta development
GO:0060716 labyrinthine layer blood vessel development
GO:0070141 response to UV-A
GO:0071260 cellular response to mechanical stimulus
GO:0071363 cellular response to growth factor stimulus
GO:0071456 cellular response to hypoxia
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097194 execution phase of apoptosis
GO:1901653 cellular response to peptide
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0036064 ciliary basal body
Protein Structure and Domains
PDB ID MGI:87986
InterPro IPR000719 Protein kinase domain
IPR001849 Pleckstrin homology domain
IPR011009 Protein kinase-like domain
PFAM PF00069
Post-translational Modifications
PhosphoSite PhosphoSite-
UniProt Splice Variant
Entrez Gene 11651
UniGene Mm.6645
MGI Symbol Akt1
EMBL AC124373 KF836746
GenPept AHA61678