Mus musculus Gene: Akt1
Summary
InnateDB Gene IDBG-174623.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akt1
Gene Name thymoma viral proto-oncogene 1
Synonyms Akt; PKB; PKB/Akt; PKBalpha; Rac
Species Mus musculus
Ensembl Gene ENSMUSG00000001729
Encoded Proteins
thymoma viral proto-oncogene 1
thymoma viral proto-oncogene 1
thymoma viral proto-oncogene 1
thymoma viral proto-oncogene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Akt1 is a Ser/Thr protein kinase that plays a pivotal role in functional activation in macrophages. Akt1 specifically functions in phagocytosis, intracellular bacterial infection, LPS tolerance, production of inflammatory cytokines/mediators, and migration during macrophage-mediate innate immunity.
Akt1 activation is blocked by Bacillus anthracis, resulting in the opening of a connexin ATP release channel and induction of macrophage death. Constitutive activation of Akt1 interferes with inflammasome activation and Il1b production, which compromises antimicrobial immunity.
Akt1 functions downstream of Tlr2-stimulation to induce the expression of the monocyte chemoattractant protein 1, Ccl2.
Lysophosphatidic acid plays an anti-inflammatory role in macrophages by diminishing lipopolysaccharide-induced phosphorylation of Mapk14 and Akt1, as well as Rela nuclear translocation.
The Akt1/Mir199a/Cav1 pathway is a regulator of innate immunity that is dysfunctional in cystic fibrosis macrophages contributing to lung hyper-inflammation.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] AKT1 is a Ser/Thr protein kinase that plays a pivotal role in functional activation in macrophages. AKT1 specifically functions in phagocytosis, intracellular bacterial infection, LPS tolerance, production of inflammatory cytokines/mediators, and migration during macrophage-mediate innate immunity.
[Homo sapiens] AKT1 activation is blocked by Bacillus anthracis, resulting in the opening of a connexin ATP release channel and induction of macrophage death. Constitutive activation of AKT1 interferes with inflammasome activation and IL1B production, which compromises antimicrobial immunity. (Demonstrated in murine model)
[Homo sapiens] AKT1 functions downstream of TLR2-stimulation to induce the expression of the monocyte chemoattractant protein 1, CCL2. (Demonstrated in mice)
[Homo sapiens] AKT1 is important for establishing the inflammatory microenvironment in the airway upon exposure to rhinovirus.
Entrez Gene
Summary This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:112653821-112674884
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000001780 ENSMUSP00000001780
ENSMUST00000128300 ENSMUSP00000122222
ENSMUST00000159815
ENSMUST00000123563
ENSMUST00000127588
ENSMUST00000144550 ENSMUSP00000123689
ENSMUST00000130342 ENSMUSP00000118190
ENSMUST00000139388
ENSMUST00000127902
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 254 interaction(s) predicted by orthology.
Experimentally validated
Total 86 [view]
Protein-Protein 86 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 254 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0042802 identical protein binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0001649 osteoblast differentiation
GO:0001893 maternal placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0005979 regulation of glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006412 translation
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006924 activation-induced cell death of T cells
GO:0006954 inflammatory response
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0007281 germ cell development
GO:0007568 aging
GO:0008286 insulin receptor signaling pathway
GO:0008637 apoptotic mitochondrial changes
GO:0009725 response to hormone
GO:0010507 negative regulation of autophagy
GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport
GO:0010765 positive regulation of sodium ion transport
GO:0010907 positive regulation of glucose metabolic process
GO:0010951 negative regulation of endopeptidase activity
GO:0010975 regulation of neuron projection development
GO:0015758 glucose transport
GO:0016310 phosphorylation
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0030030 cell projection organization
GO:0030163 protein catabolic process
GO:0030212 hyaluronan metabolic process
GO:0030307 positive regulation of cell growth
GO:0030334 regulation of cell migration
GO:0031018 endocrine pancreas development
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0031999 negative regulation of fatty acid beta-oxidation
GO:0032094 response to food
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032287 peripheral nervous system myelin maintenance
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032869 cellular response to insulin stimulus
GO:0032880 regulation of protein localization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034405 response to fluid shear stress
GO:0035556 intracellular signal transduction
GO:0042593 glucose homeostasis
GO:0042640 anagen
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045600 positive regulation of fat cell differentiation
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045792 negative regulation of cell size
GO:0045861 negative regulation of proteolysis
GO:0045907 positive regulation of vasoconstriction
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046326 positive regulation of glucose import
GO:0046329 negative regulation of JNK cascade
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0060709 glycogen cell differentiation involved in embryonic placenta development
GO:0060716 labyrinthine layer blood vessel development
GO:0070141 response to UV-A
GO:0071260 cellular response to mechanical stimulus
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071456 cellular response to hypoxia
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097194 execution phase of apoptosis
GO:1901653 cellular response to peptide
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0015630 microtubule cytoskeleton
GO:0036064 ciliary basal body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
Innate Immune System pathway
Apoptosis pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
GPCR downstream signaling pathway
PI3K/AKT activation pathway
CD28 dependent PI3K/Akt signaling pathway
Disease pathway
Hemostasis pathway
Signaling by Wnt pathway
eNOS activation and regulation pathway
Signaling by GPCR pathway
Signaling by Insulin receptor pathway
Signaling by WNT in cancer pathway
Membrane Trafficking pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
eNOS activation pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
KSRP destabilizes mRNA pathway
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
AKT-mediated inactivation of FOXO1A pathway
PIP3 activates AKT signaling pathway
Negative regulation of the PI3K/AKT network pathway
Metabolism pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
PDE3B signalling pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
deactivation of the beta-catenin transactivating complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Activation of BAD and translocation to mitochondria pathway
AKT phosphorylates targets in the nucleus pathway
Signaling by EGFR pathway
GPVI-mediated activation cascade pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
CD28 co-stimulation pathway
TCF dependent signaling in response to WNT pathway
Costimulation by the CD28 family pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
VEGFR2 mediated vascular permeability pathway
PI3K Cascade pathway
VEGFA-VEGFR2 Pathway pathway
Fc epsilon receptor (FCERI) signaling pathway
PI3K/AKT Signaling in Cancer pathway
CTLA4 inhibitory signaling pathway
Signalling by NGF pathway
Gene Expression pathway
Regulation of gene expression in beta cells pathway
Activation of BH3-only proteins pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
Developmental Biology pathway
GAB1 signalosome pathway
Regulation of beta-cell development pathway
Metabolism of nitric oxide pathway
IRS-related events pathway
AKT phosphorylates targets in the cytosol pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
G-protein beta:gamma signalling pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
G beta:gamma signalling through PI3Kgamma pathway
Downregulation of ERBB2:ERBB3 signaling pathway
PKB-mediated events pathway
Signaling by FGFR pathway
Platelet Aggregation (Plug Formation) pathway
Signaling by EGFR in Cancer pathway
Translocation of GLUT4 to the plasma membrane pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
DAP12 interactions pathway
DAP12 signaling pathway
Intrinsic Pathway for Apoptosis pathway
KEGG
Tight junction pathway
Endometrial cancer pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
VEGF signaling pathway pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Acute myeloid leukemia pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Colorectal cancer pathway
Fc epsilon RI signaling pathway pathway
Melanoma pathway
MAPK signaling pathway pathway
Glioma pathway
mTOR signaling pathway pathway
Small cell lung cancer pathway
Adipocytokine signaling pathway pathway
Apoptosis pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Non-small cell lung cancer pathway
Focal adhesion pathway
B cell receptor signaling pathway pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Osteoclast differentiation pathway
Carbohydrate digestion and absorption pathway
Toxoplasmosis pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
INOH
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PDGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Alpha6Beta4Integrin pathway
AndrogenReceptor pathway
Notch pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
Wnt pathway
TNFalpha pathway
Hedgehog pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
IL9 pathway
RANKL pathway
Leptin pathway
TSH pathway
TSLP pathway
FSH pathway
TWEAK pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
REACTOME
AKT phosphorylates targets in the nucleus pathway
Negative regulation of the PI3K/AKT network pathway
AKT phosphorylates targets in the cytosol pathway
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
CTLA4 inhibitory signaling pathway
CD28 dependent PI3K/Akt signaling pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
GPVI-mediated activation cascade pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
G beta:gamma signalling through PI3Kgamma pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
Downregulation of ERBB2:ERBB3 signaling pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
KSRP destabilizes mRNA pathway
Activation of BAD and translocation to mitochondria pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
eNOS activation pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Translocation of GLUT4 to the plasma membrane pathway
AKT-mediated inactivation of FOXO1A pathway
Regulation of gene expression in beta cells pathway
Signaling by FGFR in disease pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
eNOS activation and regulation pathway
Signaling by Wnt pathway
Signaling by VEGF pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Signaling by GPCR pathway
Innate Immune System pathway
Regulation of beta-cell development pathway
Metabolism of nitric oxide pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated vascular permeability pathway
G-protein beta:gamma signalling pathway
deactivation of the beta-catenin transactivating complex pathway
Fc epsilon receptor (FCERI) signaling pathway
Apoptosis pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Adaptive Immune System pathway
Activation of BH3-only proteins pathway
Immune System pathway
TCF dependent signaling in response to WNT pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
PI3K/AKT Signaling in Cancer pathway
Intrinsic Pathway for Apoptosis pathway
Metabolism pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Gene Expression pathway
Disease pathway
Hemostasis pathway
Membrane Trafficking pathway
KEGG
mTOR signaling pathway pathway
Acute myeloid leukemia pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Colorectal cancer pathway
Non-small cell lung cancer pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Apoptosis pathway
MAPK signaling pathway pathway
Melanoma pathway
Endometrial cancer pathway
Tight junction pathway
Glioma pathway
Small cell lung cancer pathway
Insulin signaling pathway pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Chronic myeloid leukemia pathway
Adipocytokine signaling pathway pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Carbohydrate digestion and absorption pathway
Hepatitis C pathway
INOH
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
IGF1 signaling pathway pathway
PDGF signaling pathway pathway
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
Nephrin/Neph1 signaling in the kidney podocyte
FOXA2 and FOXA3 transcription factor networks
CD40/CD40L signaling
Nongenotropic Androgen signaling
Ceramide signaling pathway
TCR signaling in na´ve CD8+ T cells
Thromboxane A2 receptor signaling
E-cadherin signaling in the nascent adherens junction
IL8- and CXCR2-mediated signaling events
Caspase Cascade in Apoptosis
LPA receptor mediated events
Class I PI3K signaling events mediated by Akt
Aurora A signaling
CXCR4-mediated signaling events
Reelin signaling pathway
IL8- and CXCR1-mediated signaling events
Coregulation of Androgen receptor activity
TCR signaling in na´ve CD4+ T cells
Integrins in angiogenesis
VEGFR3 signaling in lymphatic endothelium
Signaling events mediated by PTP1B
ErbB1 downstream signaling
mTOR signaling pathway
a6b1 and a6b4 Integrin signaling
IGF1 pathway
FoxO family signaling
p53 pathway
Integrin-linked kinase signaling
Glucocorticoid receptor regulatory network
p75(NTR)-mediated signaling
FGF signaling pathway
Endothelins
BCR signaling pathway
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
Retinoic acid receptors-mediated signaling
IL4-mediated signaling events
ErbB2/ErbB3 signaling events
S1P3 pathway
Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by VEGFR1 and VEGFR2
HIF-1-alpha transcription factor network
Plasma membrane estrogen receptor signaling
Signaling events mediated by the Hedgehog family
Hedgehog signaling events mediated by Gli proteins
CXCR3-mediated signaling events
Fc-epsilon receptor I signaling in mast cells
VEGFR1 specific signals
IL2 signaling events mediated by PI3K
IL6-mediated signaling events
Insulin Pathway
Insulin-mediated glucose transport
Regulation of Telomerase
IFN-gamma pathway
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.410698 Mm.6645
RefSeq NM_001165894 NM_009652 XM_006515415 XM_006515416
OMIM
CCDS CCDS26194
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas