InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgs17

Summary

InnateDB Protein

IDBP-538428.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs17

Protein Name

regulator of G-protein signaling 17

Synonyms

6430507P11Rik; Rgsz2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116291

InnateDB Gene

IDBG-130367 (Rgs17)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. {ECO:0000269PubMed:15827571, ECO:0000269PubMed:16900103}.

Subcellular Localization

Membrane {ECO:0000269PubMed:16900103}; Lipid-anchor {ECO:0000269PubMed:16900103}. Nucleus {ECO:0000269PubMed:16900103}. Cytoplasm {ECO:0000269PubMed:16900103}. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the hypothalamus, periaqueductal gray matter, and pons-medulla. Lower levels in the thalamus, cortex and spinal cord. Weak expression in the striatum and cerebellum. {ECO:0000269PubMed:15827571}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity