InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zeb1

Summary

InnateDB Protein

IDBP-538436.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zeb1

Protein Name

zinc finger E-box binding homeobox 1

Synonyms

[delta]EF1; 3110032K11Rik; AREB6; BZP; MEB1; Nil2; TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124395

InnateDB Gene

IDBG-127909 (Zeb1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0007417	central nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0010464	regulation of mesenchymal cell proliferation
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0030857	negative regulation of epithelial cell differentiation
GO:0033081	regulation of T cell differentiation in thymus
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048513	organ development
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048598	embryonic morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0048752	semicircular canal morphogenesis
GO:0051150	regulation of smooth muscle cell differentiation
GO:0051216	cartilage development
GO:0071230	cellular response to amino acid stimulus
GO:0090103	cochlea morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

MGI:1344313

InterPro

IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like

PFAM

PF00096

PRINTS

PIRSF

SMART

SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E9PXY5

UniProt Splice Variant

Entrez Gene

21417

UniGene

Mm.487317

RefSeq

MGI ID

MGI Symbol

Zeb1

OMIM

CCDS

HPRD

IMGT

EMBL

AC127028 AC138619

GenPept