Version 5.4
Mus musculus Protein: Ucp2
Summary
InnateDB Protein IDBP-538553.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ucp2
Protein Name uncoupling protein 2 (mitochondrial, proton carrier)
Synonyms Slc25a8;
Species Mus musculus
Ensembl Protein ENSMUSP00000115598
InnateDB Gene IDBG-201460 (Ucp2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000303 response to superoxide
GO:0001666 response to hypoxia
GO:0006839 mitochondrial transport
GO:0007565 female pregnancy
GO:0007568 aging
GO:0010942 positive regulation of cell death
GO:0032869 cellular response to insulin stimulus
GO:0034198 cellular response to amino acid starvation
GO:0043066 negative regulation of apoptotic process
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070542 response to fatty acid
GO:0071333 cellular response to glucose stimulus
GO:0097421 liver regeneration
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID MGI:109354
InterPro IPR002030 Mitochondrial brown fat uncoupling protein
IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain
PFAM PF00153
PRINTS PR00784
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YZG5
UniProt Splice Variant
Entrez Gene 22228
UniGene Mm.171378
RefSeq
MGI ID
MGI Symbol Ucp2
OMIM
CCDS
HPRD
IMGT
EMBL AC117215
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca