InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBM22

Summary

InnateDB Protein

IDBP-53896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBM22

Protein Name

RNA binding motif protein 22

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000199814

InnateDB Gene

IDBG-53894 (RBM22)

Protein Structure

UniProt Annotation

Function

Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. {ECO:0000269PubMed:17045351, ECO:0000269PubMed:21122810, ECO:0000269PubMed:22246180}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Mainly located in the nucleus. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005487	nucleocytoplasmic transporter activity
GO:0008270	zinc ion binding
GO:0017069	snRNA binding
GO:0036002	pre-mRNA binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0000398	mRNA splicing, via spliceosome
GO:0033120	positive regulation of RNA splicing
GO:0035690	cellular response to drug
GO:0045292	mRNA cis splicing, via spliceosome
GO:0090316	positive regulation of intracellular protein transport