InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEDD2

Summary

InnateDB Protein

IDBP-53906.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEDD2

Protein Name

death effector domain containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000336972

InnateDB Gene

IDBG-53904 (DEDD2)

Protein Structure

UniProt Annotation

Function

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:11965497}. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.

Disease Associations

Tissue Specificity

Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels. {ECO:0000269PubMed:11741985, ECO:0000269PubMed:11965497}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0030159	receptor signaling complex scaffold activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006396	RNA processing
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0016075	rRNA catabolic process
GO:0019725	cellular homeostasis
GO:0030262	apoptotic nuclear changes
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway