Homo sapiens Gene: DEDD2
Summary
InnateDB Gene IDBG-53904.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEDD2
Gene Name death effector domain containing 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160570
Encoded Proteins
death effector domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:42198598-42220140
Strand Reverse strand
Band q13.2
Transcripts
ENST00000336034 ENSP00000336972
ENST00000602075
ENST00000598415
ENST00000600559
ENST00000593561
ENST00000598090
ENST00000593804
ENST00000598727 ENSP00000469233
ENST00000602201
ENST00000598200 ENSP00000469898
ENST00000601135
ENST00000595337 ENSP00000470082
ENST00000596251 ENSP00000471512
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030159 receptor signaling complex scaffold activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006396 RNA processing
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0016075 rRNA catabolic process
GO:0019725 cellular homeostasis
GO:0030262 apoptotic nuclear changes
GO:0035556 intracellular signal transduction
GO:0042981 regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL M0QXK7 M0QYK9
UniProt Splice Variant
Entrez Gene 162989
UniGene Hs.515432
RefSeq XM_006723063 NM_001270614 NM_001270615 NM_133328
HUGO HGNC:24450
OMIM
CCDS CCDS12597 CCDS59391
HPRD 10868
IMGT
EMBL AC006486 AC010247 AC098778
GenPept
RNA Seq Atlas 162989