Version 5.4
Mus musculus Protein: Mlh1
Summary
InnateDB Protein IDBP-539197.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mlh1
Protein Name mutL homolog 1 (E. coli)
Synonyms 1110035C23Rik; AI317206; AI325952; AI561766;
Species Mus musculus
Ensembl Protein ENSMUSP00000119170
InnateDB Gene IDBG-202755 (Mlh1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 135 interaction(s) predicted by orthology.
Predicted by orthology
Total 135 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003697 single-stranded DNA binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0032137 guanine/thymine mispair binding
GO:0043566 structure-specific DNA binding
Biological Process
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000712 resolution of meiotic recombination intermediates
GO:0002204 somatic recombination of immunoglobulin genes involved in immune response
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006974 cellular response to DNA damage stimulus
GO:0007060 male meiosis chromosome segregation
GO:0007126 meiotic nuclear division
GO:0007129 synapsis
GO:0007131 reciprocal meiotic recombination
GO:0007140 male meiosis
GO:0007283 spermatogenesis
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0043060 meiotic metaphase I plate congression
GO:0045132 meiotic chromosome segregation
GO:0045190 isotype switching
GO:0045950 negative regulation of mitotic recombination
GO:0048477 oogenesis
GO:0051257 spindle midzone assembly involved in meiosis
Cellular Component
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0001673 male germ cell nucleus
GO:0005694 chromosome
GO:0005712 chiasma
GO:0032389 MutLalpha complex
Protein Structure and Domains
PDB ID MGI:101938
InterPro IPR003594 Histidine kinase-like ATPase, ATP-binding domain
PFAM PF02518
PF13581
PRINTS
PIRSF
SMART SM00387
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F6R1G0
UniProt Splice Variant
Entrez Gene 17350
UniGene Mm.486383
RefSeq
MGI ID
MGI Symbol Mlh1
OMIM
CCDS
HPRD
IMGT
EMBL AC126677 AC132832
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca