Version 5.4
Mus musculus Protein: Gfra1
Summary
InnateDB Protein IDBP-539747.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gfra1
Protein Name glial cell line derived neurotrophic factor family receptor alpha 1
Synonyms AU042498;
Species Mus musculus
Ensembl Protein ENSMUSP00000120333
InnateDB Gene IDBG-180306 (Gfra1)
Protein Structure
UniProt Annotation
Function Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 and isoform 2 are expressed in heart, brain, lung, liver, kidney and testis. {ECO:0000269PubMed:9592044}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
Biological Process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
GO:0009653 anatomical structure morphogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0019898 extrinsic component of membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID MGI:1100842
InterPro IPR003438 Glial cell line-derived neurotrophic factor receptor
IPR003503 Glial cell line-derived neurotrophic factor receptor, alpha 1
IPR016017 GDNF/GAS1
IPR017372 Glial cell line-derived neurotrophic factor receptor, alpha 1/2
PFAM PF02351
PRINTS PR01316
PR01317
PIRSF PIRSF038071
SMART SM00907
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97785
PhosphoSite PhosphoSite-
TrEMBL Q9QWK2
UniProt Splice Variant
Entrez Gene 14585
UniGene Mm.488676
RefSeq
MGI ID
MGI Symbol Gfra1
OMIM
CCDS CCDS38028
HPRD
IMGT
EMBL AB000800 AC102457 AC102610 AF012811 AF014117 AF015172 BC054378 CH466585
GenPept AAB65855 AAB86599 AAB86600 AAH54378 BAA19185 EDL01795 EDL01796

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca