InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dhodh

Summary

InnateDB Protein

IDBP-539766.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhodh

Protein Name

dihydroorotate dehydrogenase

Synonyms

2810417D19Rik; AI834883;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115934

InnateDB Gene

IDBG-191275 (Dhodh)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004152	dihydroorotate dehydrogenase activity
GO:0004158	dihydroorotate oxidase activity
GO:0008144	drug binding
GO:0010181	FMN binding
GO:0048039	ubiquinone binding

Biological Process

GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222	UMP biosynthetic process
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0031000	response to caffeine
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0043065	positive regulation of apoptotic process
GO:0044205	'de novo' UMP biosynthetic process
GO:0055114	oxidation-reduction process
GO:0090140	regulation of mitochondrial fission

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:1928378

InterPro

IPR005719 Dihydroorotate dehydrogenase, class 2
IPR012135 Dihydroorotate dehydrogenase, class 1/ 2

PFAM

PF01180

PRINTS

PIRSF

PIRSF000164

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35435

PhosphoSite

PhosphoSite-

TrEMBL

Q3UET5

UniProt Splice Variant

Entrez Gene

56749

UniGene

Mm.411062

RefSeq

MGI ID

MGI Symbol

Dhodh

OMIM

CCDS

HPRD

IMGT

EMBL

AC125162 AF029667 AK149350 BC019542 BC027829 BC045206

GenPept

AAB82948 AAH19542 AAH27829 AAH45206 BAE28826