InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxo7

Summary

InnateDB Protein

IDBP-539816.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo7

Protein Name

F-box protein 7

Synonyms

2410015K21Rik; A230052G17Rik; AI117679; AW260462; C85118;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120840

InnateDB Gene

IDBG-181890 (Fbxo7)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000422	mitochondrion degradation
GO:0006626	protein targeting to mitochondrion
GO:0016567	protein ubiquitination
GO:0031647	regulation of protein stability
GO:0045620	negative regulation of lymphocyte differentiation
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle