Version 5.4
Mus musculus Gene: Fbxo7
Summary
InnateDB Gene IDBG-181890.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxo7
Gene Name F-box protein 7
Synonyms 2410015K21Rik; A230052G17Rik; AI117679; AW260462; C85118
Species Mus musculus
Ensembl Gene ENSMUSG00000001786
Encoded Proteins
IDBP-181892
F-box protein 7
IDBP-400604
F-box protein 7
IDBP-400603
F-box protein 7
IDBP-539816
F-box protein 7
IDBP-538946
F-box protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100225:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:86021972-86051873
Strand Forward strand
Band C1
Transcripts
ENSMUST00000001837 ENSMUSP00000001837
ENSMUST00000120344 ENSMUSP00000113222
ENSMUST00000117597 ENSMUSP00000113263
ENSMUST00000130320 ENSMUSP00000120840
ENSMUST00000147168 ENSMUSP00000119334
ENSMUST00000134490
ENSMUST00000130383
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000422 mitochondrion degradation
GO:0006626 protein targeting to mitochondrion
GO:0016567 protein ubiquitination
GO:0031647 regulation of protein stability
GO:0045620 negative regulation of lymphocyte differentiation
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100225
View Gene Order
ENSBTAG00000020634
Not yet available
Cross-References
SwissProt Q3U7U3
TrEMBL Q3UGI9
UniProt Splice Variant
Entrez Gene 69754
UniGene Mm.44236
RefSeq NM_153195 XM_006514058 XM_006514059
OMIM
CCDS CCDS24095
HPRD
IMGT
MGI ID MGI:1917004
MGI Symbol Fbxo7
EMBL AC122919 AK147797 AK147907 AK150626 AK151025 AK152513 BC032153 CH466539
GenPept AAH32153 BAE28145 BAE28219 BAE29716 BAE30043 BAE31276 EDL21433
RNA Seq Atlas 69754

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca