Mus musculus Gene: Fbxo7
InnateDB Gene IDBG-181890.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxo7
Gene Name F-box protein 7
Synonyms 2410015K21Rik; A230052G17Rik; AI117679; AW260462; C85118
Species Mus musculus
Ensembl Gene ENSMUSG00000001786
Encoded Proteins
F-box protein 7
F-box protein 7
F-box protein 7
F-box protein 7
F-box protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100225:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:86021972-86051873
Strand Forward strand
Band C1
ENSMUST00000001837 ENSMUSP00000001837
ENSMUST00000120344 ENSMUSP00000113222
ENSMUST00000117597 ENSMUSP00000113263
ENSMUST00000130320 ENSMUSP00000120840
ENSMUST00000147168 ENSMUSP00000119334
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000422 mitochondrion degradation
GO:0006626 protein targeting to mitochondrion
GO:0016567 protein ubiquitination
GO:0031647 regulation of protein stability
GO:0045620 negative regulation of lymphocyte differentiation
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0043234 protein complex
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
SwissProt Q3U7U3
UniProt Splice Variant
Entrez Gene 69754
UniGene Mm.44236
RefSeq NM_153195 XM_006514058 XM_006514059
MGI ID MGI:1917004
MGI Symbol Fbxo7
EMBL AC122919 AK147797 AK147907 AK150626 AK151025 AK152513 BC032153 CH466539
GenPept AAH32153 BAE28145 BAE28219 BAE29716 BAE30043 BAE31276 EDL21433
RNA Seq Atlas 69754