InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sgms1

Summary

InnateDB Protein

IDBP-539829.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sgms1

Protein Name

sphingomyelin synthase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117336

InnateDB Gene

IDBG-158524 (Sgms1)

Protein Structure

UniProt Annotation

Function

Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types (By similarity). Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. {ECO:0000250, ECO:0000269PubMed:16879426, ECO:0000269PubMed:22580896}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is widely expressed, isoform 2 shows a more narrow distribution and isoform 3 is detected only in testis and heart. {ECO:0000269PubMed:16226406}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0033188	sphingomyelin synthase activity
GO:0047493	ceramide cholinephosphotransferase activity

Biological Process

GO:0006686	sphingomyelin biosynthetic process
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0010628	positive regulation of gene expression
GO:0016049	cell growth
GO:0016310	phosphorylation
GO:0071222	cellular response to lipopolysaccharide
GO:0071356	cellular response to tumor necrosis factor
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0000138	Golgi trans cisterna
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030173	integral component of Golgi membrane

Protein Structure and Domains

PDB ID

MGI:2444110

InterPro

IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
IPR001660 Sterile alpha motif domain
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF01569
PF00536

PRINTS

PIRSF

SMART

SM00014
SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VCQ6