InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prlr

Summary

InnateDB Protein

IDBP-540258.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prlr

Protein Name

prolactin receptor

Synonyms

AI987712; Pr-1; Pr-3; Prlr-rs1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118355

InnateDB Gene

IDBG-129218 (Prlr)

Protein Structure

UniProt Annotation

Function

This is a receptor for the anterior pituitary hormone prolactin.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004925	prolactin receptor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007259	JAK-STAT cascade
GO:0007595	lactation
GO:0030155	regulation of cell adhesion
GO:0030856	regulation of epithelial cell differentiation
GO:0038161	prolactin signaling pathway
GO:0060644	mammary gland epithelial cell differentiation
GO:0060736	prostate gland growth
GO:0060749	mammary gland alveolus development
GO:0061180	mammary gland epithelium development