Version 5.4
Mus musculus Protein: Tlr8
Summary
InnateDB Protein IDBP-540370.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tlr8
Protein Name toll-like receptor 8
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000122089
InnateDB Gene IDBG-185523 (Tlr8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0008144 drug binding
Biological Process
GO:0002282 microglial cell activation involved in immune response
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0034158 toll-like receptor 8 signaling pathway
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045356 positive regulation of interferon-alpha biosynthetic process
GO:0045359 positive regulation of interferon-beta biosynthetic process
GO:0045416 positive regulation of interleukin-8 biosynthetic process
GO:0050707 regulation of cytokine secretion
GO:0051607 defense response to virus
GO:0052033 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2176887
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A2AHI8
UniProt Splice Variant
Entrez Gene 170744
UniGene Mm.196676
RefSeq
MGI ID
MGI Symbol Tlr8
OMIM
CCDS
HPRD
IMGT
EMBL AL731735
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca