InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC1A4

Summary

InnateDB Protein

IDBP-54043.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC1A4

Protein Name

solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

Synonyms

ASCT1; SATT;

Species

Homo sapiens

Ensembl Protein

ENSP00000234256

InnateDB Gene

IDBG-54041 (SLC1A4)

Protein Structure

UniProt Annotation

Function

Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.

Subcellular Localization

Membrane {ECO:0000269PubMed:17081065}; Multi-pass membrane protein {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0015175	neutral amino acid transmembrane transporter activity
GO:0015180	L-alanine transmembrane transporter activity
GO:0015184	L-cystine transmembrane transporter activity
GO:0015186	L-glutamine transmembrane transporter activity
GO:0015193	L-proline transmembrane transporter activity
GO:0015194	L-serine transmembrane transporter activity
GO:0015195	L-threonine transmembrane transporter activity
GO:0017153	sodium:dicarboxylate symporter activity
GO:0034590	L-hydroxyproline transmembrane transporter activity

Biological Process

GO:0006811	ion transport
GO:0006821	chloride transport
GO:0006835	dicarboxylic acid transport
GO:0006865	amino acid transport
GO:0006868	glutamine transport
GO:0015808	L-alanine transport
GO:0015811	L-cystine transport
GO:0015824	proline transport
GO:0015825	L-serine transport
GO:0015826	threonine transport
GO:0034589	hydroxyproline transport
GO:0035249	synaptic transmission, glutamatergic
GO:0035524	proline transmembrane transport
GO:0050890	cognition
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0042470	melanosome
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome