Version 5.4
Mus musculus Protein: Cul2
Summary
InnateDB Protein IDBP-540455.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cul2
Protein Name cullin 2
Synonyms 1300003D18Rik; 4932411N15Rik; AI327301; mKIAA4106;
Species Mus musculus
Ensembl Protein ENSMUSP00000125403
InnateDB Gene IDBG-127755 (Cul2)
Protein Structure
UniProt Annotation
Function Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 389 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 389 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0032403 protein complex binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0030163 protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0030891 VCB complex
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031462 Cul2-RING ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:1918995
InterPro IPR001373 Cullin, N-terminal
IPR016158 Cullin homology
IPR016159 Cullin repeat-like-containing domain
IPR019559 Cullin protein, neddylation domain
PFAM PF00888
PF10557
PRINTS
PIRSF
SMART SM00182
SM00884
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D4H8
PhosphoSite PhosphoSite-Q9D4H8
TrEMBL Q571A2
UniProt Splice Variant
Entrez Gene 71745
UniGene Mm.291707
RefSeq NP_083678
MGI ID
MGI Symbol Cul2
OMIM
CCDS CCDS29032
HPRD
IMGT
EMBL AK016520 AK160597 AK220287 BC025902 BC026779 BC027428
GenPept AAH25902 AAH26779 AAH27428 BAB30283 BAD90212 BAE35903

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca