InnateDB Protein
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IDBP-540561.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Abca7
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Protein Name
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ATP-binding cassette, sub-family A (ABC1), member 7
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Synonyms
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Abc51; ABCX;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000115111
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InnateDB Gene
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IDBG-171979 (Abca7)
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Protein Structure
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Function |
Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. {ECO:0000269PubMed:12917409, ECO:0000269PubMed:15550377, ECO:0000269PubMed:16908670}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney.
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Disease Associations |
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Tissue Specificity |
Widely expressed with higher expression in brain, lung, adrenal gland and spleen (at protein level). Highly expressed in spleen and hematopoietic tissues. {ECO:0000269PubMed:11435699, ECO:0000269PubMed:12917409, ECO:0000269PubMed:15550377}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1351646
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InterPro |
IPR003439
ABC transporter-like
IPR003593
AAA+ ATPase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00005
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PRINTS |
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PIRSF |
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SMART |
SM00382
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TIGRFAMs |
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Modification |
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SwissProt |
Q91V24
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PhosphoSite |
PhosphoSite-Q91V24
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
27403
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UniGene |
Mm.103351
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RefSeq |
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MGI ID |
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MGI Symbol |
Abca7
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OMIM |
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CCDS |
CCDS24004
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HPRD |
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IMGT |
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EMBL |
AF213395
AF287141
AF287142
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GenPept |
AAF31434
AAK56862
AAK56863
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