Version 5.4
Mus musculus Protein: Sgms1
Summary
InnateDB Protein IDBP-540829.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sgms1
Protein Name sphingomyelin synthase 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000115785
InnateDB Gene IDBG-158524 (Sgms1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0033188 sphingomyelin synthase activity
GO:0047493 ceramide cholinephosphotransferase activity
Biological Process
GO:0006686 sphingomyelin biosynthetic process
GO:0006954 inflammatory response
GO:0010628 positive regulation of gene expression
GO:0016049 cell growth
GO:0071222 cellular response to lipopolysaccharide
GO:0071356 cellular response to tumor necrosis factor
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000138 Golgi trans cisterna
GO:0030173 integral component of Golgi membrane
Protein Structure and Domains
PDB ID MGI:2444110
InterPro IPR001660 Sterile alpha motif domain
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
PFAM PF00536
PRINTS
PIRSF
SMART SM00454
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E3W996
UniProt Splice Variant
Entrez Gene 208449
UniGene Mm.444083
RefSeq XP_006526884
MGI ID
MGI Symbol Sgms1
OMIM
CCDS
HPRD
IMGT
EMBL AC113485 AC115752 AC124323 AC158130
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca