InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irak1

Summary

InnateDB Protein

IDBP-541297.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irak1

Protein Name

interleukin-1 receptor-associated kinase 1

Synonyms

AA408924; Il1rak; IRAK; IRAK-1; IRAK1-S; mPLK; Plpk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116167

InnateDB Gene

IDBG-154747 (Irak1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 112 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	49 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	112 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005149	interleukin-1 receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0019221	cytokine-mediated signaling pathway
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032494	response to peptidoglycan
GO:0032496	response to lipopolysaccharide
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070498	interleukin-1-mediated signaling pathway

Cellular Component

Protein Structure and Domains

PDB ID

MGI:107420

InterPro

IPR011009 Protein kinase-like domain

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B1AUW1

UniProt Splice Variant

Entrez Gene

16179

UniGene

Mm.38241

RefSeq

MGI ID

MGI Symbol

Irak1

OMIM

CCDS

HPRD

IMGT

EMBL

AL672002

GenPept