InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdc26

Summary

InnateDB Protein

IDBP-541534.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc26

Protein Name

cell division cycle 26

Synonyms

2010012C09Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120496

InnateDB Gene

IDBG-153053 (Cdc26)

Protein Structure

UniProt Annotation

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0007067	mitotic nuclear division
GO:0030071	regulation of mitotic metaphase/anaphase transition
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0070979	protein K11-linked ubiquitination